Target and tissue selectivity of PROTAC degraders - Chemical Society Reviews (RSC Publishing) DOI:10.1039/D2CS00200K
Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins | Journal of Medicinal Chemistry
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
The Power of PROTACs - LifeSensors
a) PROTAC-mediated ternary complex formation and Hook effect as a... | Download Scientific Diagram
Current strategies for improving limitations of proteolysis targeting chimeras
Characterizing PROTAC ternary complex formation using Biacore SPR systems | Cytiva
Accelerating PROTAC drug discovery: Establishing a relationship between ubiquitination and target protein degradation
a) Relative levels of target protein are plotted against PROTAC... | Download Scientific Diagram
Design, synthesis, and biological evaluation of small molecule PROTACs for potential anticancer effects | Medicinal Chemistry Research
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS) | Protocol
A suite of mathematical solutions to describe ternary complex formation and their application to targeted protein degradation by
Hypoxia deactivates epigenetic feedbacks via enzyme-derived clicking proteolysis-targeting chimeras | Science Advances
Allosteric modulators can exacerbate the hook effect by reducing... | Download Scientific Diagram
Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs - ScienceDirect
Frontiers | From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation
Pharmaceutics | Free Full-Text | A Mechanistic Pharmacodynamic Modeling Framework for the Assessment and Optimization of Proteolysis Targeting Chimeras (PROTACs)
An AURKA PROTAC cocktail relieves the hook effect. A) Scheme depicting... | Download Scientific Diagram
Current strategies for the design of PROTAC linkers: a critical review
PROTAC-mediated ternary complex formation and hook effect. The hook... | Download Scientific Diagram
